To quantify selection acting on a trait, methods have been developed using either within or between-species variation. However, methods using within-species variation do not …
Models have always been central to inferring molecular evolution and to reconstructing phylogenetic trees. Their use typically involves the development of a mechanistic framework …
Adaptation in protein-coding sequences can be detected from multiple sequence alignments across species or alternatively by leveraging polymorphism data within a population. Across …
Phylogenetic codon models are routinely used to characterize selective regimes in coding sequences. Their parametric design, however, is still a matter of debate, in particular …
Molecular sequences are shaped by selection, where the strength of selection relative to drift is determined by effective population size ($N_e$). Populations with high $N_e$ are …
Mutation--selection phylogenetic codon models are grounded on population genetics first principles and represent a principled approach for investigating the intricate interplay …
In recent years, codon substitution models based on the mutation--selection principle have been extended for the purpose of detecting signatures of adaptive evolution in …
In humans and many other species, recombination events cluster in narrow and short-lived hot spots distributed across the genome, whose location is determined by the Zn-finger …
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Duis posuere tellus ac convallis placerat. Proin tincidunt magna sed ex sollicitudin condimentum.
